Iis - Open An .EXE File From A Site?

Can I open executable files on a client machine from an ASP.NET site hosted on IIS?

I have tried using the following code in ASP.NET:

Process notePad = new Process();
notePad.StartInfo.FileName = "notepad.exe";
notePad.StartInfo.Arguments = @"E:abc.txt";
notePad.StartInfo.CreateNoWindow = false;
notePad.StartInfo.UseShellExecute = false;
notePad.StartInfo.RedirectStandardOutput = false;
notePad.Start();

and also in Javascript with the following code:

function Launch() {
var w = new ActiveXObject("WScript.Shell");
w.run('notepad.exe');
return true;
}

But both snippets will only open the file when the site is not hosted in IIS.